As an animal actively navigates, or is passively carried through its environment, its eyes receive continuous visual motion signals generated by its movement relative to the surroundings. How does the vertebrate brain process such visual information and prepare appropriate locomotor and eye movement behavior?
Our group investigates the underlying neural circuits in zebrafish larvae. We aim to understand how optic flow is filtered by the optic tectum and the pretectum to mediate behavioral responses.
Furthermore, we study how local networks produce function in the (pre-) motor systems in the hindbrain. The neural integrator for horizontal eye movements forms a short-lived memory of eye positions by maintaining eye-position related neural activity in the absence of input. It serves as a paradigm to identify mechanisms of short-term information storage, which is also needed in many other vertebrate brain areas of higher complexity.
Recently, we began to characterize the identified circuits also in the context of zebrafish natural habitats and behavioral needs, aiming to better understand the specific tasks the zebrafish brain performs.
We use a combination of optogenetics, two-photon microscopy, genetics, behavioral assays, as well as other physiological approaches and computation to investigate the architecture and mechanisms of the larval neural circuitry.
For further information, please also visit our web page arrenberg-lab.de .
- Wang K., Hinz J., Zhang Y., Thiele T. R., Arrenberg A. B. (2020) Parallel channels for motion feature extraction in the pretectum and tectum of larval zebrafish. Cell Reports 2020 Jan 14;30(2):442-453.e6. doi: 10.1016/j.celrep.2019.12.031
- Brysch C., Leyden C., Arrenberg A. B. (2019) Functional architecture underlying binocular coordination of eye position and velocity in the larval zebrafish hindbrain. BMC Biology 17, Article number: 110 (2019)
- Zhang Y. & Arrenberg A. B. (2019) High throughput, rapid receptive field estimation for global motion sensitive neurons using a contiguous motion noise stimulus. Journal of Neuroscience Methods, Volume 326 doi: 10.1016/j.jneumeth.2019.108366
- Wang K., Hinz J., Haikala V., Reiff D. F.& Arrenberg A. B. (2019) Selective processing of all rotational and translational optic flow directions in the zebrafish pretectum and tectum. BMC Biology 17, Article number: 29 (2019)
- Ecke G. A., Bruijns S. A., Hölscher J., Mikulasch F. A., Witschel T., Arrenberg A. B., Mallot H. A. (2019) Sparse Coding Predicts Optic Flow Specificities of Zebrafish Pretectal Neurons. Neural Comput & Applic (2019)
- Dehmelt F. A., von Darányi A., Leyden C., Arrenberg A. B. (2018) Evoking and Tracking Zebrafish Eye Movement in Multiple Larvae with ZebEyeTrack. Nature Protocols 13(7): pp. 1539–1568. doi: 10.1038/s41596-018-0002-0
- Reinig S., Driever W., Arrenberg A. B. (2017) The Descending Diencephalic Dopamine System Is Tuned to Sensory Stimuli. Current Biology 27(3): pp. 318–333. doi: 10.1016/j.cub.2016.11.059
- Kubo F., Hablitzel B., dal Maschio M., Driever W., Baier H., Arrenberg A. B. (2014) Functional Architecture of an Optic Flow-Responsive Area That Drives Horizontal Eye Movements in Zebrafish. Neuron 81(6): pp. 1344-1359. doi: 10.1016/j.neuron.2014.02.043
- Gonçalves P. J., Arrenberg A. B., Hablitzel B., Baier H., Machens C. K. (2014) Optogenetic perturbations reveal the dynamics of an oculomotor integrator. Front Neural Circuits. 2014 Feb 28;8:10. doi: 10.3389/fncir.2014.00010. eCollection 2014