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Organization: Werner Reichardt Centre for Integrative Neuroscience
Phone number: +49 7071 29 89182
Department: CIN Retinal Circuits and Optogenetics
Position: Head of Research Group
Area: CIN Members
Scientific topic: Retinal Circuits and Optogenetics
Field of Research
We study the structure and function of retinal circuits in the healthy retina. We are interested in aspects of retinal function spanning all level, from the role of individual molecular signalling components, to the global control of retinal function by adaptation mechanisms. We apply our knowledge of normal retinal function to the treatment of retinal degeneration, by using optogenetic tools to restore retinal function after photoreceptor cell death.
Single-cell patch clamp recordings, multi-electrode array electrophysiology, and 2-photon imaging of retinal tissue in-vitro; behavioral studies; optogenetics
behavioural neuroscience; computational neuroscience; degeneration / regeneration; neuro-physiology; neuro-prosthetics; visual system; retina
- Münch TA, da Silveira RA, Siegert S, Viney TJ, Awatramani GB, Roska B (2009). Approach sensitivity in the retina processed by a multifunctional neural circuit. Nat Neurosci. 12(10):1308-16.
- Lagali PS, Balya D, Awatramani GB, Münch TA, Kim DS, Busskamp V, Cepko CL, Roska B (2008). Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat Neurosci. 11(6):667-75.
- Fried SI, Münch TA, Werblin FS (2002). Mechanisms and circuitry underlying directional selectivity in the retina. Nature. 420(6914):411-4.