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Dr. Jing Hu

Organization: Werner Reichardt Centre for Integrative Neuroscience

Address:

Otfried-Müller-Str. 25
72076 Tübingen
Germany

Department: CIN Sensory Mechanotransduction

Position: Head of Research Group

Area: CIN Members (Alumni)

Scientific topic: Sensory Mechanotransduction


Field of Research

Animals have developed sophisticated sensory neural system in order to rapidly respond to the environmental change. The main interest of us is to understand the molecular and cellular mechanism of our senses of touch and pain. How does the sensory neuron transduce the physical stimulus such as pressure and stretch into electrical signals? What are the molecular components underlying mechanotransduction? And how is the encoded information transmitted to the central nervous system?  One of our particular interests at this moment is to explore how these transduction and transmission are altered under pathologic condition.

Methods

cell lines and primary sensory neurons culture, organotypic spinal cord slice culture; extracellular recordings from sensory afferents, patch clamp recordings and calcium imaging from primary senosory neurons and cells lines; behavioral testing in animal models of pain; molecular biology; mass spectrometry; immunohistochemistry; micro-contact printing technique to guide the neurite outgrowth

Keywords

cell culture (organotypic); molecular & cellular neurobiology; neuro-physiology; pain; signal transduction; somatosensory system; tissue engineering


Publications
  1. Hu J, Chiang LY, Koch M, Lewin GR (2010). Evidence for a protein tether involved in somatic touch. EMBO J. 29(4):855-67.
  2. Wetzel C, Hu J, Riethmacher D, Benckendorff A, Harder L, Eilers A, Moshourab R, Kozlenkov A, Labuz D, Caspani O, Erdmann B, Machelska H, Heppenstall PA, Lewin GR (2007). A stomatin-domain protein essential for touch sensation in the mouse. Nature. 445(7124):206-9.
  3. Hu J, Lewin GR (2006). Mechanosensitive currents in the neurites of cultured mouse sensory neurones. J Physiol. 577:815-28.