Large-Scale Neuronal Interactions

The central goal of our laboratory is to investigate how cognition and behavior emerges from large-scale interactions across widely distributed neuronal ensembles. How do sophisticated cognitive processes such as perception, decision-making, and motor behavior emerge from large-scale interactions across the brain? Which neural mechanisms coordinate these interactions, how are they dynamically regulated in a goal-directed fashion, and how are these interactions disturbed in neuropsychiatric diseases?

We believe that, in order to successfully address these questions, it is key to link large-scale population measures of neuronal activity to circuit and cellular-level mechanisms. To this end, our lab combines human (MEG/EEG) and animal electrophysiology. A central aim of the lab is to integrate these two lines of research.

Spectral fingerprints of large-scale neuronal interactions

To investigate large-scale neuronal interactions, we focus on the fine temporal structure of neuronal activity. Neuronal activity exhibits oscillations, i.e. periodicity, at various different frequencies and spatial scales. This structure may be key to understanding the neuronal mechanisms underlying large-scale interactions. Oscillations may serve as highly informative markers, or ‘spectral fingerprints’ of the circuit interactions involved in different cognitive functions 

Spectral fingerprints in the ‘resting brain’

In one line of research, we investigate these spectral fingerprints with MEG and EEG in the resting human brain, i.e. without a specific behavioral task. We investigate how networks of brain regions spontaneously coordinate their oscillations at different frequencies and how these large-scale oscillatory interactions are altered in the diseased human brain. Our recent results suggest that oscillatory resting-state interactions may indeed provide sensitive markers for brain pathologies.

Task-specific neuronal interactions

In another line of research, we investigate large-scale neuronal interactions underlying specific cognitive functions. We focus on decision-making and memory as two fundamental cognitive processes that involve flexible interactions across distributed cortical and sub-cortical networks. We study these interactions with M/EEG in humans and with large-scale microelectrode recordings in animals. 

Understanding neuronal interactions in the healthy brain is a prerequisite for unraveling how these interactions are disturbed in the diseased brain. We aim to translate our research into the clinical context to better identify, understand and treat neuropsychiatric disorders. 

Group Leader

    Markus Siegel

    Large-Scale Neuronal Interactions
    Werner Reichardt Centre for Integrative Neuroscience
    Otfried-Müller-Straße 25
    72076 Tübingen

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News & Press
March 25 2015
Upcoming CIN Workshops

'Games of the Brain' series: Perception and Reasoning with S. Siegel

March 21 2015
Do-It-Yourself Neuroscience

Scientists of the University of Tübingen work internationally to offer research and training opportunities in the life sciences in developing countries, using 3D printing and affordable materials.

December 30 2014
Pointless Torture of Experimental Animals by Tübingen Neuroscientists?

Open letter by CIN chairman Peter Thier

December 13 2014
CIN Workshops: Games of the Brain Naturalizing Agency

Saturday, 13th December 2014 | 9.30am - 6.30pm | Hörsaal Forum Scientiarum (Doblerstr. 33, 72074 Tübingen)