Prof. Dr. Thomas Gasser

  Name Contact
Prof. Dr. Thomas Gasser Prof. Dr. Thomas Gasser
Email:write Email
Tel.:+49 (0)7071 29 86529
www:website
Adr.:Dept. for Neurodegenerative Diseases
Hertie Institute for Clinical Brain Research
Hoppe-Seyler-Straße 3
 72076 Tübingen
 Germany
Area / Position CIN-Member
Department Neurodegenerative Diseases, HIH
Scientific topic Biomarkers of Parkinson's disease
Field of research To identify markers for an earlier diagnosis and disease progression in Parkinson's disease (PD). Large genome wide association studies are being done to define risk as well as protecitve markers for the disease. In large prospective cohort studies risk and premotor markers are assessed. Subjects are followed longitudinally to define the relative risk and predictive value of the respective markers. Similarly longitudinal follow up of motor and non-motor symptoms in cohorts of PD patients in different stages are done to define the best suitable progression markers for better validation of treatment strategies. A special focus is put on the definition premotor and progression markers in monogenetic PD. Biomaterial including DNA, RNA, CSF and fibroblast is stored in a large biobank for determination of biomarkers. Findings will be translated into our animal models for better understanding of the pathophysiology and development of therapeutic strategies.
Methods genome-wide association studies (GWAS), linkage studies, genotyping, LRRK2 transgenic mouse model system, primary cell culture, induced pluripotent stem (iPS) cells, biobanking, functional neuroimaging, MRI, transcranial sonography, ambulatory sleep recording, neuropsychological testing, quantitatvie sensory and autonomic testing, accelerometry, determination of olfaction
Publications
  1. Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, et al. (2009). Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 41(12):1308-12.
  2. Maetzler W, Liepelt I, Berg D (2009). Progression of Parkinson's disease in the clinical phase: potential markers. Lancet Neurol. 8(12):1158-71.
  3. Liepelt I, Behnke S, Schweitzer K, Wolf B, Godau J, Wollenweber F, et al. (2009). Pre-motor signs of PD are related to SN hyperechogenicity assessed by TCS in an elderly population. Neurobiol Aging. [Epub ahead of print]
Keywords biomarkers; brain imaging; clinical neurosciences; degeneration / regeneration; neuro-genetics; neurology; neuronal stem cells
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News & Press
April 14 2015
Tübinger Fenster für Forschung

The „Tübinger Fenster für Forschung“ (TÜFFF) on May 8th 2015 offers a glimpse of the top-level research performed in Tübingen - the CIN makes a showing with no less than eight booths.


April 13 2015
ACTION DIALOGUES | Public Lecture Series

The Public Lecture Series ACTION DIALOGUES brings together some of the leading figures of the major theoretical perspectives on action in Philosophy, Psychology, and Neuroscience.

March 25 2015
"Dem Gehirn beim Denken zusehen"

Scientists of the University of Tübingen decode mechanisms of associative learning in mice (press release in German).


March 21 2015
Do-It-Yourself Neuroscience

Scientists of the University of Tübingen work internationally to offer research and training opportunities in the life sciences in developing countries, using 3D printing and affordable materials.