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Prof. Dr. Thomas Gasser

  Name Contact
Prof. Dr. Thomas Gasser Prof. Dr. Thomas Gasser
Email:write Email
Tel.:+49 (0)7071 29 86529
www:website
Adr.:Dept. for Neurodegenerative Diseases
Hertie Institute for Clinical Brain Research
Hoppe-Seyler-Straße 3
 72076 Tübingen
 Germany
Area / Position CIN-Member
Department Neurodegenerative Diseases, HIH
Scientific topic Biomarkers of Parkinson's disease
Field of research To identify markers for an earlier diagnosis and disease progression in Parkinson's disease (PD). Large genome wide association studies are being done to define risk as well as protecitve markers for the disease. In large prospective cohort studies risk and premotor markers are assessed. Subjects are followed longitudinally to define the relative risk and predictive value of the respective markers. Similarly longitudinal follow up of motor and non-motor symptoms in cohorts of PD patients in different stages are done to define the best suitable progression markers for better validation of treatment strategies. A special focus is put on the definition premotor and progression markers in monogenetic PD. Biomaterial including DNA, RNA, CSF and fibroblast is stored in a large biobank for determination of biomarkers. Findings will be translated into our animal models for better understanding of the pathophysiology and development of therapeutic strategies.
Methods genome-wide association studies (GWAS), linkage studies, genotyping, LRRK2 transgenic mouse model system, primary cell culture, induced pluripotent stem (iPS) cells, biobanking, functional neuroimaging, MRI, transcranial sonography, ambulatory sleep recording, neuropsychological testing, quantitatvie sensory and autonomic testing, accelerometry, determination of olfaction
Publications
  1. Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, et al. (2009). Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 41(12):1308-12.
  2. Maetzler W, Liepelt I, Berg D (2009). Progression of Parkinson's disease in the clinical phase: potential markers. Lancet Neurol. 8(12):1158-71.
  3. Liepelt I, Behnke S, Schweitzer K, Wolf B, Godau J, Wollenweber F, et al. (2009). Pre-motor signs of PD are related to SN hyperechogenicity assessed by TCS in an elderly population. Neurobiol Aging. [Epub ahead of print]
Keywords biomarkers; brain imaging; clinical neurosciences; degeneration / regeneration; neuro-genetics; neurology; neuronal stem cells
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News & Press
October 12 2014
CIN Advisory Board Member John Duncan (Oxford University)

expresses his support for the research carried out at the MPI for Biological Cybernetics, Tübingen.


October 6 2014
4th Joint CIN - NIPS Symposium

Information can be found here.