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Prof. Dr. Mathias Jucker

Organization: Hertie Institute of Clinical Brain Research / DZNE Tübingen

Address:

Otfried-Müller-Str. 27
72076 Tübingen
Germany

Phone number: +49 (0)7071 29 86863

Department: Dept. of Cellular Neurology

Area: CIN Members

Scientific topic: Brain Aging and Alzheimer's Disease


Field of Research

The research focus of the department is on the cellular and molecular mechanisms of brain aging and age-related neurodegenerative diseases with a special focus on the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathies.

Methods

Transgenic mouse models; in vivo multiphoton imaging; neuro-stereology

Keywords

brain imaging; glia; neuro-immunology; neuro-pathology; neuro-plasticity; neurodegeneration


Publications
  1. Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret J, Paganetti P, Walsh DM, Mathews P, Ghiso J, Staufenbiel M, Walker L, Jucker M (2006) Exogenous induction of Afl-amyloidogenesis is governed by intrinsic properties of agent and host. Science. 313(5794):1781-4.
  2. Kaeser SA, Herzig MC, Coomaraswamy J, Kilger E, Selenica MLB, Winkler D, Staufenbiel M, Levy E, Grubb A, Jucker M (2007). Cystatin C modulates cerebral fl-amyloidosis. Nat Genet. 39(12):1437-9.
  3. Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, Jucker M (2009). Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci. 2012(11):1361-3.