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Prof. Dr. Holger Lerche

Organization: Hertie Institute for Clinical Brain Research

Address:

Otfried-Müller-Str. 27
72076 Tübingen
Germany

Phone number: +49 (0)7071 29 80442

Department: Experimental Epileptology, Center for Neurology

Area: CIN Members


Field of Research

The research group of the Department of Neurology and Epileptology is interested to link the molecular mechanisms of defined, mainly genetic, neurological diseases with their clinical symptoms. The main goals are (i) to find out specific disease-causing genetic defects, (ii) understand their molecular and cellular pathomechanisms to ultimately (iii) improve existing or develop new therapies. The research is concentrated on diseases with disturbed neuronal excitability caused by mutations in ion channels, receptors or transporters. These have the advantage that we can examine their gating mechanisms in molecular detail using electrophysiological techniques such as patch clamping.