Field of Research
Heading the group ‘Neurophysiology & Interventional Neuropsychiatry’ at the Department of Psychiatry and Psychotherapy my research focus is on the behavioral and neurophysiological effects, mechanisms and modulators of brain stimulation. Transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and deep brain stimulation (DBS) are used for the assessment and modification of healthy as well as disturbed cortical function e.g. in tinnitus, auditory hallucinations, Tourette syndrome and depression. Exploration of the neurophysiological correlates of these effects as assessed with electroencephalography (EEG), evoked potentials (EP), peripheral neurophysiology and near infrared spectroscopy (NIRS) provides new insights into the interaction of brain activity and stimulation. This knowledge is used to develop new options to treat neuropsychiatric disorders and test their efficacy in controlled clinical trials.
Plewnia C, Schroeder PA, Wolkenstein L (2015) Targeting the biased brain: non-invasive brain stimulation to ameliorate cognitive control. Lancet Psychiatry 2(4):351-6.
Plewnia C (2015) Cosmetic neurosurgery, ethics, and enhancement - Author's reply. Lancet Psychiatry 2(7):586-7.
Schroeder PA, Lohmann J, Butz MV, Plewnia C (2015) Behavioral Bias for Food Reflected in Hand Movements: A Preliminary Study with Healthy Subjects. Cyberpsychol Behav Soc Netw. 2015 Nov 12. [Epub ahead of print]
Plewnia C, Schroeder PA, Kunze R, Faehling F, Wolkenstein L (2015) Keep calm and carry on: improved frustration tolerance and processing speed by transcranial direct current stimulation (tDCS). PLoS One 10(4):e0122578.
Wolkenstein L, Plewnia C (2013) Amelioration of cognitive control in depression by transcranial direct current stimulation. Biological Psychiatry 73:646-51
Plewnia C, Zwissler B, Längst I, Maurer B, Giel K, Krüger R. (2013) Effects of transcranial direct current stimulation (tDCS) on executive functions: influence of COMT Val/Met polymorphism. Cortex 49:1801-7.
Plewnia C, Vonthein R, Wasserka B, Arfeller C, Naumann A, Schraven SP, Plontke SK. (2012) Treatment of chronic tinnitus with theta burst stimulation: A randomized controlled trial. Neurology 78:1628-34.
Rzesnitzek L, Waechter T, Gharabaghi A, Kruger R, and Plewnia C. (2011) Suppression of extrapyramidal side effects of doxepin by thalamic DBS for Tourette Syndrome. Neurology 77:1708-9
Dockery C, Hueckel-Weng R, Birbaumer N, Plewnia C. (2009) Enhancement of planning ability by transcranial direct current stimulation. Journal of Neuroscience 29:7271–7277.