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Prof. Dr. Christian la Fougère

Organization: University Hospital Tübingen

Address:

Otfried-Müller-Str. 14
72076 Tübingen
Germany

Phone number: +49 (0)7071 29-8 65 53

Department: Division for Nuclear Medicine and Clinical Molecular Imaging

Area: CIN Members


Field of Research

Molecular imaging (MI) is paving the way for precision and personalized medicine. We aim to test and to implement new molecular imaging probes for different neurological (e.g. epilepsy) and neurodegenerative diseases (dementia and parkinsonian syndromes) as well as brain tumors, in order to obtain a better characterization of the underlying molecular changes in the brain in vivo. We aim to use those multi-parametric imaging techniques in order to provide an insight in physiological (adaptive) as well as pathophysiological changes in the brain, which might lead to an individualized treatment stratification for our patients in the future.

Methods

Molecular imaging techniques using radiolabeled pharmaceuticals and positron-emission-tomography (PET) are increasingly used for the assessment of pathobiochemical and pathophysiological changes in the brain. New generation hybrid PET-MR scanner enable the simultaneous acquisition of molecular (PET) as well as morphological and functional (chemical shifts, flow, diffusion, blood oxygenation and perfusion) changes (MR) in vivo, that might in addition give new insights in the processes of brain plasticity.


Publications

la Fougere C*,  Zwergal A*, Rominger A, Förster S, Fesl G, Dieterich M, Brandt T, Strupp M, Bartenstein P, Jahn K.  Real versus Imagined Locomotion: an intraindividual [18F]-FDG PET - fMRI comparison. Neuroimage  2010;50(4):1589-1598

la Fougere C,  Grant S, Kostikov A, Schirrmacher R, Gravel P, Schipper H, Reader A, Evans A, Thiel A. Where in-vivo imaging meets cytoarchitectonics: the relationship between cortical thickness and neuronal density measured with High-Resolution [18F]flumazenil-PET. Neuroimage. 2011;56(3):951-60 

Zwergal A*, la Fougère C*, Lorenzl S, Rominger A, Xiong G, Deutschenbaur L, Linn J, Krafczyk S, Dieterich M, Brandt T, Strupp M, Bartenstein P, Jahn J. Postural imbalance and falls in PSP correlate with functional pathology of the thalamus. Neurology. 2011;12(2):101-9 

Jansen N, Graute V, Armbruster L, Suchorska B, Lutz J, Eigenbrod S, Cumming P, Bartenstein P, Tonn JC, Kreth FW, la Fougère C. MRI-suspected Low Grade Glioma: is there a need to perform dynamic FET-PET? Eur J Nucl Med Mol Imaging 2012;39(6):1021-9

Jansen N, Suchorska B, Wenter V, Eigenbrod S, Schmid-Tannwald C, Zwergal A, Niyazi M, Drexler M, Bartenstein P, Schnell O, Tonn JC, Thon N, Kreth FW, la Fougère C. Dynamic FET-PET in newly diagnosed astrocytic low grade glioma identifies high risk patients. J Nucl Med. 2014 Feb;55(2):198-203