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Prof. Dr. Bernd Antkowiak

Organization: University Hospital Tübingen

Address:

Waldhörnlestr. 22
72072 Tübingen
Germany

Phone number: +49 (0)7071 29 81121

Department: Dept. of Anesthesiology and Intensive Care, Experimental Anesthesiology Section

Area: CIN Members

Scientific topic: GABA(A)-receptor-subtypes, anesthetics, cerebral cortex, spinal cord


Field of Research

Anesthetic agents in current clinical use display little molecular selectivity and therefore produce a large number of unwanted side effects. We hypothesize that essential components of anesthesia such as unconsciousness, amnesia and immobility can, in principle, be achieved by highly selective pharmacological interventions. Research into the recently discovered various subtypes of the GABA(A)-receptor is expected to translate into drugs with an improved side effect profile. Therefore it is a major aim of our group to elucidate how these subtypes modulate information processing in the cerebral cortex and spinal cord.

Methods

Our investigations are based on a combination of different methods including genetically modified mice, specifically designed chemical compounds, different cell culture models, the patch-clamp technique and standard extracellular electrophysiology.

Keywords

anaesthesia; cell culture (organotypic); molecular & cellular neurobiology; neuro-pharmacology; neuro-physiology


Publications
  1. Rudolph U, Antkowiak B (2004). Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci. 5(9):709-20.
  2. Grasshoff C, Jurd R, Rudolph U, Antkowiak B (2007). Modulation of presynaptic beta3-containing GABA(A) receptors limits the immobilizing actions of GABAergic anesthetics. Mol Pharmacol. 72(3):780-7.
  3. Drexler B, Jurd R, Rudolph U, Antkowiak B (2009). Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors. Neuropharmacology. 57(4):446-55.