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Prof. Dr. Anthony Gummer

Organization: University Hospital Tübingen

Address:

Elfriede-Aulhorn-Str. 5
72076 Tübingen
Germany

Phone number: +49 (0)7071 29 88191

Department: Dept. of Otolaryngology, Section of Physiological Acoustics & Communication

Area: CIN Members

Scientific topic: Auditory Biophysics


Field of Research

Our mission is to understand the basis of sound processing by the healthy and pathological cochlea, as well as to develop new tools for differential diagnosis. Research into sound processing, in collaboration with Dr. Harasztosi, aims at understanding: 1) mechanoelectrical transduction in hair-cell stereocilia, 2) electromechanical transduction in outer hair cells, 3) cochlear amplification, and 4) calcium-related homeostatic mechanisms.  Development of diagnostic tools, in collaboration with Dr. Dalhoff, entails elucidating mechanisms of: 1) the generation of otoacoustic emissions, and 2) retrograde transmission through the middle ear, as well as developing: 1) optimum stimulus strategies, and 2) laserinterferometric recording techniques for non-invasive assessment of cochlear emissions in patients.

Methods

patch clamping of hair cells in isolation and in organotypical culture; calcium imaging using a two-photon confocal laser-scanning microscope; nanomechanics of isolated outer hair cells and of the organ of Corti, using atomic-force spectroscopy; laser interferometry; electrocochleography; audiometry, including otoacoustic emissions; mathematical modeling

Keywords

auditory system; biomechanics; cell culture (organotypic); clinical neurosciences; cochlear biophysics; molecular & cellular neurobiology; neuro-physiology


Publications
  1. Vetesník A, Turcanu D, Dalhoff E, Gummer AW (2009). Extraction of sources of distortion product otoacoustic emissions by onset-decomposition. Hear Res. 256(1-2):21-38.
  2. Dalhoff E, Turcanu D, Zenner HP, Gummer AW (2007). Distortion product otoacoustic emissions measured as vibration on the eardrum of human subjects. Proc Natl Acad Sci USA. 104(5):1546-51.
  3. Kaneko T, Harasztosi C, Mack AF, Gummer AW. (2006). Membrane traffic in outer hair cells of the adult mammalian cochlea. Eur J Neurosci. 23(10):2712-22.