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Prof. Dr. Alireza Gharabaghi

Organization: Werner Reichardt Centre for Integrative Neuroscience

Address:

Otfried-Müller-Str. 45
72076 Tübingen
Germany

Phone number: +49 (0) 7071 29 85849

Department: CIN Neuroprosthetics & Functional Neurosurgery

Position: Head of Research Group

Area: CIN Members

Scientific topic: Brain-computer interfaces & Neuromodulation


Field of Research

Neurotechnological advances provide us with increasingly powerful devices to interface brain tissue and computational hardware for potential neuroprosthetic and neurorehabilitative applications in severely handicapped patients after stroke or neurodegenerative diseases. In experimental settings, these brain-machine-interfaces (BMI) allow us to record and/or stimulate cortical circuits in order to control robotic arms or to restore motor function. Nonetheless, widespread clinical application is limited yet due to variable stability and performance of current BMI strategies in humans. We strive to study real-time, closed-loop approaches of recording and stimulation in order to evaluate adaptive neuromodulation strategies with non-invasive or implanted BMI for neurorehabilitation of function and with the goal of translating this know-how into clinical use.

Methods

Recording of brain signals on different levels (single cells, local field potentials, electrocorticograms, electroencephalography), modulating neural circuits by micro- and macrostimulation techniques, closed-loop neuromodulation, brain-robot interfaces

Keywords

brain imaging; clinical neurosciences; brain stimulation; motor system; neuro-plasticity; neuro-prosthetics; neuromodulation; neurorehabilitation; robotics; neuroimplants; brain-interfaces


Publications

1: Kraus D, Naros G, Bauer R, Leão MT, Ziemann U, Gharabaghi A. Brain-robot interface driven plasticity: Distributed modulation of corticospinal excitability. Neuroimage. 2015 Oct 23. pii: S1053-8119(15)00979-9. doi: 10.1016/j.neuroimage.2015.09.074.

2: Vukelić M, Gharabaghi A. Oscillatory entrainment of the motor cortical network during motor imagery is modulated by the feedback modality. Neuroimage. 2015 May 1;111:1-11. doi: 10.1016/j.neuroimage.2015.01.058.

3: Weiss D, Klotz R, Govindan RB, Scholten M, Naros G, Ramos-Murguialday A, Bunjes F, Meisner C, Plewnia C, Krüger R, Gharabaghi A. Subthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson's disease. Brain. 2015 Mar;138(Pt 3):679-93. doi: 10.1093/brain/awu380.

4: Bauer R, Fels M, Vukelić M, Ziemann U, Gharabaghi A. Bridging the gap between motor imagery and motor execution with a brain-robot interface. Neuroimage. 2015 Mar;108:319-27. doi: 10.1016/j.neuroimage.2014.12.026.

5: Becker HG, Haarmeier T, Tatagiba M, Gharabaghi A. Electrical stimulation of the human homolog of the medial superior temporal area induces visual motion blindness. J Neurosci. 2013 Nov 13;33(46):18288-97. doi: 10.1523/JNEUROSCI.0556-13.2013.

6: Vukelić M, Bauer R, Naros G, Naros I, Braun C, Gharabaghi A. Lateralized alpha-band cortical networks regulate volitional modulation of beta-band sensorimotor oscillations. Neuroimage. 2014 Feb 15;87:147-53. doi: 10.1016/j.neuroimage.2013.10.003.

7: Schuepbach WM, et al. ……,  Gharabaghi A, ………, Deuschl G; EARLYSTIM Study Group. Neurostimulation for Parkinson's disease with early motor complications. N Engl J Med. 2013 Feb 14;368(7):610-22. doi:10.1056/NEJMoa1205158.

8: Gharabaghi A, Kraus D, Leão MT, Spüler M, Walter A, Bogdan M, Rosenstiel W, Naros G, Ziemann U. Coupling brain-machine interfaces with cortical stimulation for brain-state dependent stimulation: enhancing motor cortex excitability for neurorehabilitation. Front Hum Neurosci. 2014 Mar 5;8:122. doi: 10.3389/fnhum.2014.00122.