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Dr. Ingrid Ehrlich

Organization: Hertie Institute for Clinical Brain Research

Address:

Otfried-Müller-Str. 25
72076 Tübingen
Germany

Phone number: +49 (0)7071 2989189

Department: HIH / CIN Physiology of Learning and Memory

Position: Head of Research Group

Area: CIN Members

Scientific topic: Physiology of Learning and Memory


Field of Research

We investigate the cellular and synaptic basis of learning and memory processes. We focus on classical (Pavlovian) fear conditioning and its extinction in mice, which are powerful models for associative learning and memory. The key brain structure implicated in acquisition and storage of fear memory is the amygdala. Some of the strongest links between synaptic and cellular plasticity and behavioural learning come from studies of sensory inputs to the amygdala. Our aim is to study other elements of the amygdaloid network, including inhibitory elements, and their interactions with other amygdala input and output structures. Understanding fear and extinction memory is not only an excellent model for general principles of memory formation in the brain, but will also provide leads on nervous system dysfunction during inappropriate control of fear behavior in conditions such as human anxiety disorders.

Methods

Patch-clamp recordings, two-photon microscopy, molecular biology, histology, viral gene transfer in vivo, behavioral analysis

Keywords

Synaptic Plasticity; learning & memory; molecular & cellular neurobiology; neuro-physiology; neuro-plasticity


Publications
  1. Tang W, Ehrlich I, Wolff SBE, Michalski A-M, Wölfl S, Hasan M, Lüthi A, Sprengel R (2009). Faithful expression of multiple proteins via 2A-peptide self-processing: a versatile and reliable method for manipulating brain cicuits. J Neurosci. 29(27):8621-9.
  2. Ehrlich I, Humeau Y, Grenier F, Ciocchi S, Herry C, Lüthi A (2009). Amygdala inhibitory circuits and the control of fear memory. Neuron. 62(6):757-71.
  3. Ehrlich I, Klein M, Rumpel S, Malinow R (2007). PSD-95 is required for activity-driven synapse stabilization. Proc Natl Acad Sci USA. 104(10):4176-81.