In 2007, the CIN started with 25 principal investigators as cluster applicants, as stipulated in the DFG call for bids. When the CIN cluster was approved further scientists from a range of institutions were incorporated, to make up the 48 'founding members' of the CIN. Since the beginning of 2014 the CIN has consisted of over 80 scientists in total. The membership process involves an application to the steering committee in which the candidate outlines his or her scientific profile and submits a list of publications. The committee's decision is based purely on the scientific excellence of each candidate.
Prof. Dr. Ingeborg Kraegeloh-Mann
Organization: University Hospital Tübingen
Phone number: +49 (0)7071 29 84735
Department: Dept. of Paediatric Neurology and Developmental Medicine
Area: CIN Members
Scientific topic: Early Brain Lesions and Plasticity
Field of Research
Impact of early brain compromise on brain development and function. We could characterize CP (cerebral palsy) as a mainly early lesional CNS disease and are now specially interested in the organisation and reorganisation after early brain lesions (for sensorimotor functions, language and visuo-perception), which we characterize on a morphological and functional level including functional imaging and also behavioural and cognitive measures. In a EU wide network (surveillance of CP in Europe), we are involved in studying the epidemiology of CP, which is especially prevalent in preterm children.
Another field of interest is the clinical and biochemical characterization of Metachromatic Leukodystrophy and Krabbe Disease, lysosomal storage disorders leading to demyelination. Description of the natural course using standardized functional measures, recovery after bone marrow transplantation and morphology function relationship with respect to leukodystrophic changes are topics of current research.
- Behavioural measures including neuropsychology testing;
- Magnetic resonance imaging: MRS, fMRI, DTI, (in cooperation with the section of experimental MR of the CNS);
- MEG (in cooperation with the MEG centre).
brain imaging; clinical neurosciences; developmental neurobiology; language; motor system; neuro-plasticity
- Platt MJ, Cans C, Johnson A, Surman G, Topp M, Torrioli MG, Krägeloh-Mann I (2007). Trends in cerebral palsy among infants of very low birthweight (<1500g) or born prematurely (<32 weeks) in 16 European centres: a database study. Lancet. 369:43-50.
- Krägeloh-Mann I, Horber V (2007). The role of magnetic resonance imaging in elucidating the pathogenesis of cerebral palsy: a systematic review. Dev Med Child Neurol. 49(2):144-51.
- Krägeloh-Mann I (2004). Imaging of early brain injury and cortical plasticity. Exp Neurol. 190 Suppl 1:S84-90.