In 2007, the CIN started with 25 principal investigators as cluster applicants, as stipulated in the DFG call for bids. When the CIN cluster was approved further scientists from a range of institutions were incorporated, to make up the 48 'founding members' of the CIN. Since the beginning of 2014 the CIN has consisted of over 80 scientists in total. The membership process involves an application to the steering committee in which the candidate outlines his or her scientific profile and submits a list of publications. The committee's decision is based purely on the scientific excellence of each candidate.
Field of Research
To understand how the brain functions at the molecular, cellular and circuit levels, and eventually to gain control of the brain, is the ultimate goal. One research direction is to study the underlying mechanism of neurovascular coupling by identifying the signaling molecules propagating from neurons to glia and to vessels. The other is to identify the “core switch” underlying brain arousal and coma states by combining genetic tools with optical imaging and high field fMRI. The goal is to identify candidate molecules from critical brain nuclei which can contribute to switch brain states. We are expected to translate knowledge acquired from animal models into novel therapeutic treatment for coma patients.
- <pre>Yu, X., Wadghiri, Y.Z., Sanes, D.H., and Turnbull, D.H. (2005) In vivo auditory brain mapping in mice with Mn-enhanced MRI. Nat Neurosci 8(7): 961-968. PMCID: PMC2034206.</pre>
- <pre>Yu, X., Sanes, D.H., Aristizabal, O., Wadghiri, Y.Z., and Turnbull, D.H. (2007) Large-scale reorganization of the tonotopic map in mouse auditory midbrain revealed by MRI. Proc Natl Acad Sci U S A 104 (29): 12193-12198. PMCID: 1913547.</pre>
- <pre>Yu, X., Nieman, B.J., Sudarov, A., Szulc, K.U., Abdollahian, D.J., Bhatia, N., Lalwani, A.K., Joyner, A.L., and Turnbull, D.H. (2011) Morphological and functional midbrain phenotypes in Fibroblast Growth Factor 17 mutant mice detected by Mn-enhanced MRI. Neuroimage 56(3): 1251-1258. PMCID: PMC3085550.</pre>
- <pre>Yu, X., Glen, D., Wang, S., Dodd, S., Hirano, Y., Saad, Z., Reynolds, R., Silva, A.C., and Koretsky, A.P. (2012) Direct imaging of macrovascular and microvascular contributions to BOLD fMRI in layers IV-V of the rat whisker-barrel cortex. Neuroimage 59(2): 1451-1460. PMCID: PMC3230765.</pre>
- <pre>Yu, X., Chung, S., Chen, D.Y., Wang, S., Dodd, S.J., Walters, J.R., Isaac, J.T., Koretsky, A.P. (2012) Thalamocortical inputs show post-critical-period plasticity. Neuron. 74(4) 731-42.PMID: PMC22632730</pre>
- <pre>Qian C, Yu X, Chen D, Dodd S, Bouraoud N, Pothayee N, Chen Y, Bennett K, Beeman S, Murphy-Boesch J, Koretsky A, (2013)Wireless Amplified NMR detector (WAND) for high resolution in-vivo image of internal organs, Radiology, 268:228-236. PMID: 23392428</pre>
- <pre>Yu X*, Qian C., Chen D-Y, Dodd S, and Koretsky A*, (2014) Deciphering laminar-specific neural inputs with line-scanning fMRI, Nature Methods, 11, 55–58. PMID: 24240320</pre>